Abstract The frame structure uses laminated rubber bearings base isolation, according to the basic conditions of laminated rubber bearings, using the ANSYS software to establish the calculation model of the isolated structure, the damping effect of this structure in the rare earthquake is analyzed through a specific example. Finally, two conclusions are proposed. 1)The application scope of rubber bearings base isolation is not only associated with the structure of the height to width aspect ratio, but also associated with the structure of the natural period. If the vibration period of the structure is greater than 1, the damping effect of the isolated structure will be significantly decreased. 2)Laminated rubber bearings base isolation can be applied to the pure frame structure with the following 14 floors ; the 14 layer can be used, but the damping effect is not good;14 floors above can not be used.